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Disease onset in familial and sporadic multiple sclerosis in Argentina

J I Rojas1, L Patrucco1, J MIguez1

  • 1Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.

Multiple Sclerosis and Related Disorders
|April 12, 2016
PubMed
Abstract

Insights

Younger generations with familial multiple sclerosis (MS) show an earlier age of onset compared to older generations and sporadic MS cases. This suggests an anticipation trend in familial MS.

Area of Science:

  • Neurology
  • Genetics
  • Epidemiology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Familial multiple sclerosis (FMS) involves a genetic predisposition.
  • Understanding age at onset patterns is crucial for MS research.

Purpose of the Study:

  • To investigate if there is an anticipation of age at onset in familial multiple sclerosis (FMS) compared to sporadic MS (SMS).
  • To analyze generational differences in age at onset within FMS and compare them to SMS cases in Argentina.

Main Methods:

  • A multicenter study involving 1333 patients from 14 MS Centers in Argentina.
  • Patients classified as FMS if a first or second-degree relative had MS; otherwise, classified as SMS.
  • Comparison of age at onset between FMS and SMS, and across different generations within FMS.

Main Results:

  • 97 patients (7.3%) were identified as FMS.
  • Younger FMS generations exhibited a significantly lower age at onset (24.1±3.7 years) compared to older FMS generations (30.3±5.7 years) and SMS cases (32.4±9.4 years) (p<0.001).
  • No significant difference in age at onset was found between older FMS generations and SMS cases (p=0.12).

Conclusions:

  • An anticipation of age at onset for MS was observed in younger generations of FMS patients.
  • This generational trend in FMS suggests a potential genetic anticipation phenomenon.
  • The findings highlight the importance of family history in understanding MS onset patterns.
Keywords:
ArgentinaFamilial MSMultiple sclerosisSouth America

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