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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Dengue fever in patients with multiple sclerosis taking fingolimod or natalizumab
Yara Dadalti Fragoso1, Paulo Diniz da Gama2, Sidney Gomes3
1Department of Neurology, Universidade Metropolitana de Santos, Rua da Constituição 374, CEP 11015-470 Santos, SP, Brazil.
Abstract:
Dengue fever is the most prevalent mosquito-borne viral illness in humans. There may be different clinical manifestations of the disease, from mild symptoms to hemorrhagic forms of dengue fever and even neurological complications of this viral infection. Blood cells are usually affected, and thrombocytopenia is the hallmark of the disease. This paper presents 15 cases of dengue fever in patients with multiple sclerosis (MS) taking fingolimod or natalizumab. There were no complications of dengue fever or worse outcomes of MS in these patients, and only four of them needed short-term treatment withdrawal due to lymphopenia.
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