Mitochondrial function following downhill and/or uphill exercise training in rats
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Updated: Mar 22, 2026
A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats
Published on: April 28, 2023
Anna-Isabel Schlagowski1,2, Marie-Eve Isner-Horobeti1,3, Stéphane P Dufour1,4
1Strasbourg University, Faculty of Medicine, Fédération de Médecine Translationnelle de Strasbourg, EA3072 "Mitochondria, Oxidative Stress and Muscular Protection," 4 rue Kirschleger, 67085, Strasbourg, France.
Introduction:
The goal of this study was to compare the effects of downhill (DH), uphill (UH), and UH-DH exercise training, at the same metabolic rate, on exercise capacity and skeletal muscle mitochondrial function.
Methods:
Thirty-two Wistar rats were separated into a control and 3 trained groups. The trained groups exercised for 4 weeks, 5 times per week at the same metabolic rate, either in UH, DH, or combined UH-DH. Twenty-four hours after the last training session, the soleus, gastrocnemius, and vastus intermedius muscles were removed for assessment of mitochondrial respiration.
Results:
Exercise training, at the same metabolic rate, improved maximal running speed without specificity for exercise modalities. Maximal fiber respiration was enhanced in soleus and vastus intermedius in the UH group only.
Conclusions:
Exercise training, performed at the same metabolic rate, improved exercise capacity, but only UH-trained rats enhanced mitochondrial function in both soleus and vastus intermedius skeletal muscle. Muscle Nerve 54: 925-935, 2016.
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