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Related Experiment Videos

Lateral visually-guided saccades in progressive supranuclear palsy.

C Pierrot-Deseilligny1, S Rivaud, B Pillon

  • 1Unité INSERM U 289, Hôpital de la Salpêtrière, Paris, France.

Brain : a Journal of Neurology
|April 1, 1989
PubMed
Summary

Patients with progressive supranuclear palsy (PSP) exhibit scattered saccade latency, with short latencies linked to frontal inhibition deficits and long latencies to excitatory pathway damage. This variability decreases over time.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Progressive supranuclear palsy (PSP) presents an oculomotor syndrome.
  • Understanding the pathophysiology of saccade control in PSP is crucial.

Purpose of the Study:

  • Investigate the pathophysiology of oculomotor syndrome in PSP.
  • Clarify suprareticular control of saccades in PSP patients.

Main Methods:

  • Electro-oculography was used to study lateral visually-guided saccades.
  • Two paradigms were employed: gap task and antisaccade task.
  • Neuropsychological tests assessed frontal dysfunction.

Main Results:

  • Saccade latency distribution was more scattered in PSP patients than controls.

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  • PSP patients showed a correlation between antisaccade errors and gap task latency.
  • Latency correlated with frontal dysfunction, suggesting impaired frontal inhibitory systems.

    • Conclusions:

    • Short latencies may indicate impaired frontal inhibitory systems for saccade initiation.
    • Long latencies might stem from damage to excitatory suprareticular pathways or attention circuits.
    • Longitudinal follow-up revealed decreased saccade latency variability over time, possibly due to a balance between inhibitory and excitatory pathway impairments.