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Human colon cancer HT-29 cell death responses to doxorubicin and Morus Alba leaves flavonoid extract
S Fallah1, A Karimi2, G Panahi2
1Iran University of Medical Sciences Department of Biochemistry, Faculty of Medicine Tehran Iran fallah.s@iums.ac.ir.
Abstract:
The mechanistic basis for the biological properties of Morus alba flavonoid extract (MFE) and chemotherapy drug of doxorubicin on human colon cancer HT-29 cell line death are unknown. The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated. The results showed that flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line. MFE and doxorubicin exert a cytotoxic effect on human colon cancer HT-29 cell line by probably promoting or induction of apoptosis.
