Related Experiment Video

Updated: Mar 22, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.8K

Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A

Ricardo Rivera-López1, Juan Jiménez-Jáimez1, José Mario Sabio2

  • 1Cardiology Clinical Management Unit, Granada University Hospitals; Granada Institute of Biohealth Research.Granada. Spain.

Plos One
|April 12, 2016
PubMed

Insights

Systemic lupus erythematosus (SLE) patients have prolonged QT intervals, which correlate with subclinical atherosclerosis. This finding may aid cardiovascular risk stratification in SLE management.

Area of Science:

  • Cardiology
  • Rheumatology
  • Vascular Biology

Background:

  • Systemic lupus erythematosus (SLE) is associated with a longer QT interval compared to the general population.
  • The clinical significance of prolonged QT intervals in SLE remains unclear.
  • Subclinical atherosclerosis is a known risk factor for cardiovascular events.

Purpose of the Study:

  • To investigate the relationship between QT interval and subclinical atherosclerosis in SLE patients.
  • To assess if QT interval can serve as a marker for subclinical atherosclerosis in SLE.

Main Methods:

  • A study involving 93 SLE patients and 109 healthy controls.
  • Electrocardiograms were used to measure the corrected QT interval (QTc) via Bazett's formula.
  • Carotid-femoral pulse-wave velocity (PWV) was employed to evaluate subclinical atherosclerosis.

Main Results:

  • SLE patients exhibited a significantly longer QTc interval (415 ± 21.4 ms) than controls (407 ± 19.1 ms).
  • A positive correlation was found between QTc interval and PWV in SLE patients (r = 0.235; p = 0.02).
  • This association remained significant after adjusting for hypertension and age in multivariate analysis.

Conclusions:

  • Prolonged QTc interval in SLE patients is linked to subclinical atherosclerosis.
  • QTc interval measurement may assist in cardiovascular risk stratification for SLE patients.
  • Identifying patients who could benefit from aggressive cardiovascular prevention strategies.
Abstract

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.7K

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
638
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
970
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
728
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
593