Related Experiment Video

Updated: Mar 22, 2026

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

2.2K

The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases

Verena Katharina Raker1, Christian Becker1, Kerstin Steinbrink1

  • 1Department of Dermatology, University Medical Center Mainz, Johannes Gutenberg-University Mainz , Mainz , Germany.

Frontiers in Immunology
|April 12, 2016
PubMed

Insights

Cyclic adenosine monophosphate (cAMP) regulates immune cell functions. Targeting the cAMP pathway offers potential therapeutic strategies for autoimmune and inflammatory diseases.

Area of Science:

  • Immunology
  • Cellular Biology
  • Pharmacology

Background:

  • Nucleotide signaling molecules are crucial for cellular pathway regulation.
  • Cyclic adenosine monophosphate (cAMP) is a key regulator of innate and adaptive immune cell functions.

Purpose of the Study:

  • To provide an overview of the cyclic AMP (cAMP) axis.
  • To discuss the role of cAMP in regulating immune functions.
  • To explore the clinical and translational relevance of targeting the cAMP pathway for therapeutic interventions.

Main Methods:

  • Literature review and synthesis of existing research on the cAMP signaling pathway.
  • Analysis of the impact of cAMP on immune cell functions.
  • Discussion of therapeutic strategies involving cAMP modulation.

Main Results:

  • The cAMP axis plays a significant role in modulating immune responses.
  • Interventions targeting cAMP generation or effects demonstrate immunoregulatory potential.
  • The cAMP pathway is a promising target for treating autoimmune and inflammatory disorders.

Conclusions:

  • The cAMP pathway is a critical regulator of immune cell function.
  • Modulating cAMP signaling presents viable therapeutic avenues for immune-mediated diseases.
  • Further research into cAMP-targeted therapies holds significant clinical and translational promise.
Keywords:
T cellsT regulatory cellsTregsautoimmunitycyclic AMPinflammationtargeted therapies

More Related Videos

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity10:10

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity

Published on: November 8, 2016

9.3K
Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

1.1K

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.1K
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
18.4K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
13.8K
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
9.1K
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
9.1K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
3.2K