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Updated: Mar 22, 2026
06:35
Ultrasound Assessment of Endothelial Function: A Technical Guideline of the Flow-mediated Dilation Test
Published on: April 27, 2016
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Relationship between serum triglyceride levels and endothelial function in a large community-based study
Masato Kajikawa1, Tatsuya Maruhashi2, Takeshi Matsumoto2
1Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan.
Atherosclerosis
|April 12, 2016
Summary
High triglycerides are linked to poor endothelial function, a key factor in cardiovascular events. Lowering triglyceride levels may improve blood vessel health and reduce heart disease risk.
Area of Science:
- Cardiovascular Research
- Metabolic Health
- Vascular Biology
Background:
- Low-density lipoprotein cholesterol is a known cardiovascular risk factor.
- Circulating triglycerides are increasingly recognized as a potential cardiovascular risk factor.
- Endothelial dysfunction contributes to the development of cardiovascular events.
Purpose of the Study:
- To evaluate the association between serum triglyceride levels and endothelial function in a general population.
- To determine if triglycerides are an independent predictor of endothelial function.
Main Methods:
- Cross-sectional analysis of 4887 subjects from the FMD-Japan registry.
- Assessment of endothelial function using flow-mediated vasodilation (FMD).
- Statistical analysis of serum triglyceride levels and FMD, adjusting for cardiovascular risk factors.
Main Results:
- Serum triglyceride levels showed a significant negative correlation with FMD (r = -0.12, p < 0.001).
- FMD decreased progressively with increasing triglyceride levels across six groups.
- Elevated triglyceride levels (≥1.20 mmol/L) were independently associated with lower FMD quartiles after multivariate adjustment.
Conclusions:
- Triglycerides are an independent predictor of endothelial function.
- Lowering circulating triglyceride levels may improve endothelial function.
- Potential reduction in cardiovascular events through triglyceride management.
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