Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

2.7K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.7K
Obesity01:24

Obesity

1.5K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Hypodermis01:02

Hypodermis

8.4K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
8.4K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.3K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

638
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
638
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

6.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiometabolic health effects of dietary counselling on a high-quality, fibre-rich diet in adults with type 2 diabetes: a randomised controlled trial.

The British journal of nutrition·2026
Same author

REACT-PXE: a consensus on diagnosis and future research concerning pseudoxanthoma elasticum (PXE).

Annales de dermatologie et de venereologie·2026
Same author

Optimizing coronary CT angiography with spectral dual-layer CT: motion-compensated virtual monoenergetic imaging achieves 50% contrast dose reduction in a phantom study.

The international journal of cardiovascular imaging·2025
Same author

Pseudoxanthoma Elasticum: The Diagnostic Accuracy of Genetic Testing Compared with Clinical Criteria in a Large Cohort.

The Journal of investigative dermatology·2025
Same author

Increased Intracranial Arterial Pulsatility and Microvascular Brain Damage in Pseudoxanthoma Elasticum.

AJNR. American journal of neuroradiology·2024
Same author

Diet in secondary prevention: the effect of dietary patterns on cardiovascular risk factors in patients with cardiovascular disease: a systematic review and network meta-analysis.

Nutrition journal·2024

Related Experiment Video

Updated: Mar 22, 2026

Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging
10:10

Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging

Published on: August 19, 2020

8.3K

Adipose Tissue Dysfunction: Clinical Relevance and Diagnostic Possibilities.

I M Schrover1, W Spiering1, T Leiner2

  • 1Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|April 12, 2016
PubMed
Summary

Adipose tissue dysfunction, an imbalance in inflammatory signals, contributes to metabolic diseases. Assessing adipose tissue quality, not just quantity, is key for diagnosis in all individuals.

More Related Videos

Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

42.3K
Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

45.9K

Related Experiment Videos

Last Updated: Mar 22, 2026

Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging
10:10

Exploring Adipose Tissue Structure by Methylsalicylate Clearing and 3D Imaging

Published on: August 19, 2020

8.3K
Localization, Identification, and Excision of Murine Adipose Depots
08:53

Localization, Identification, and Excision of Murine Adipose Depots

Published on: December 4, 2014

42.3K
Identification and Dissection of Diverse Mouse Adipose Depots
06:31

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

45.9K

Area of Science:

  • Endocrinology
  • Metabolic Syndrome Research
  • Cardiovascular Health

Background:

  • Adipose tissue dysfunction involves an imbalance of pro- and anti-inflammatory adipokines.
  • This imbalance leads to insulin resistance, chronic inflammation, hypercoagulability, and hypertension.
  • These conditions increase the risk of cardiovascular disease and type 2 diabetes mellitus.

Purpose of the Study:

  • To highlight the importance of adipose tissue quality over quantity in diagnosing dysfunction.
  • To discuss diagnostic modalities for assessing adipose tissue quality.
  • To identify practical clinical methods for evaluating adipose tissue dysfunction.

Main Methods:

  • Review of current understanding of adipose tissue dysfunction.
  • Exploration of diagnostic techniques including anthropometry, biopsies, and imaging.
  • Evaluation of clinical indicators like visceral adipose tissue, insulin resistance, and metabolic syndrome.

Main Results:

  • Adipose tissue dysfunction can occur in both obese and lean individuals.
  • Adipose tissue quality is a more critical factor than quantity for diagnosis.
  • Clinical indicators such as high visceral adipose tissue, insulin resistance, and metabolic syndrome are practical diagnostic markers.

Conclusions:

  • Focusing on adipose tissue quality is essential for accurate diagnosis of dysfunction.
  • Accessible clinical measures like waist circumference and metabolic syndrome assessment aid in identifying dysfunction.
  • Early identification of adipose tissue dysfunction can help mitigate risks for cardiovascular disease and type 2 diabetes.