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Updated: Mar 22, 2026

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

Rafael Franco1, Eva Martínez-Pinilla2, José L Lanciego3

  • 1Departament de Bioquímica i Biomedicina Molecular, Facultat de Biología, Universitat de BarcelonaBarcelona, Spain; Centro de Investigación Biomédica en Red: Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos IIIMadrid, Spain; Institute of Biomedicine, University of BarcelonaBarcelona, Spain.

Frontiers in Pharmacology
|April 12, 2016
PubMed
Summary

Class A G-protein-coupled receptors (GPCRs) form dimers and oligomers, challenging previous assumptions. This review presents evidence for their existence in cells and natural sources, impacting pharmacology and drug discovery.

Keywords:
GPCRdimerizationdopamine receptorheteromerhomodimerligandsmammalian receptorsignal transduction taste receptor

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