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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Managing asthma in pregnancy.

Vanessa E Murphy¹

¹Centre for Asthma and Respiratory Disease, University of Newcastle and Hunter Medical Research Institute, Newcastle, NSW, Australia.

Breathe (Sheffield, England)

|April 12, 2016

Summary

This summary is machine-generated.

Effective asthma management in pregnancy prevents exacerbations and improves outcomes. Adjusting treatment using exhaled nitric oxide (FeNO) reduces asthma attacks in pregnant women.

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Area of Science:

Obstetrics and Gynecology
Pulmonology
Allergy and Immunology

Background:

Asthma is a prevalent chronic condition in pregnancy, with increasing incidence.
Asthma exacerbations during pregnancy pose significant risks, leading to adverse maternal and fetal outcomes like low birth weight and preterm delivery.
Effective asthma management aims to maintain symptom control, preserve lung function, and ensure fetal well-being.

Purpose of the Study:

To outline the objectives and strategies for optimal asthma control during pregnancy.
To elucidate the maternal and perinatal risks associated with asthma in pregnant individuals.
To present a novel management approach proven to decrease asthma exacerbations in this population.

Main Methods:

Review of current guidelines for asthma management in pregnancy, emphasizing preconception counseling and regular antenatal reviews.
Implementation of a multidisciplinary approach integrating asthma care with obstetric management.
Utilizing exhaled nitric oxide fraction (FeNO) as a biomarker to guide inhaled corticosteroid (ICS) and long-acting beta-agonist (LABA) adjustments.

Main Results:

A strategy adjusting inhaled corticosteroid (ICS) therapy based on exhaled nitric oxide fraction (FeNO) levels significantly reduced asthma exacerbations.
Women managed with the FeNO-guided strategy received ICS at lower mean doses.
Infant respiratory health at 12 months of age showed improvement in the FeNO-guided treatment group.

Conclusions:

Asthma is the most common chronic disease complicating pregnancy.
Up to 45% of pregnant women with asthma experience exacerbations.
Treatment adjustment guided by airway inflammation markers like FeNO effectively lowers exacerbation rates in pregnant women with asthma.