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Related Experiment Video

Updated: Feb 11, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Dopamine pathway gene variants may modulate cognitive performance in the DHS - Mind Study.

Susan E Martelle1, Laura M Raffield2, Nichole D Palmer2

  • 1Department of Physiology and Pharmacology Wake Forest School of Medicine Winston - Salem North Carolina; Center for Genomics and Personalized Medicine Research Wake Forest School of Medicine Winston - Salem North Carolina.

Brain and Behavior
|April 12, 2016
PubMed
Summary

Type 2 diabetes is linked to cognitive decline. This study found that variants in the DOPA decarboxylase gene, involved in dopamine synthesis, are associated with cognitive function in individuals with type 2 diabetes.

Keywords:
CognitionDAT1 VNTRDOPA decarboxylasedopaminepolymorphismtype 2 diabetes

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Area of Science:

  • Neuroscience
  • Genetics
  • Endocrinology

Background:

  • Type 2 diabetes is associated with accelerated cognitive decline, but the underlying mechanisms are not fully understood.
  • The monoamine system, crucial for cognition, can be affected by type 2 diabetes.
  • This study investigated the link between genetic variants in dopamine pathways and cognitive function in a type 2 diabetes cohort.

Purpose of the Study:

  • To examine the association between sequence variants in dopamine metabolism genes and cognitive performance.
  • To identify specific genetic markers influencing cognitive function in individuals with type 2 diabetes.

Main Methods:

  • Genetic association analyses were conducted on candidate variants in dopaminergic and insulin signaling pathways.
  • Genome-wide and imputed data were analyzed for polymorphisms in dopamine processing genes.
  • Cognitive function was assessed using multiple standardized tests, including the Rey Auditory-Verbal Learning Task.

Main Results:

  • A DOPA decarboxylase gene variant (rs10499695) was associated with poorer performance on a measure of retroactive interference.
  • Another DOPA decarboxylase variant (rs62445903) also showed a significant association with retroactive interference.
  • These findings highlight the role of dopaminergic genes in cognitive function within the context of type 2 diabetes.

Conclusions:

  • Genetic variations in dopamine synthesis pathways, specifically within the DOPA decarboxylase gene, are linked to cognitive performance in type 2 diabetes.
  • These results provide insights into the neurobiological mechanisms connecting type 2 diabetes and cognitive impairment.