Two Cases of Hypophosphatemia with Increased Renal Phosphate Excretion in Legionella Pneumonia
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Updated: Mar 22, 2026

Use of Galleria mellonella as a Model Organism to Study Legionella pneumophila Infection
Published on: November 22, 2013
Shuhei Watanabe1, Keiji Kono1, Hideki Fujii2
1Division of Nephrology and Kidney Center, Kobe University Graduate School of Medicine, Kobe, Japan; Division of Nephrology, Akashi Medical Center, Akashi, Japan.
Abstract:
We encountered 2 cases of hypophosphatemia due to Legionella pneumonia. Both cases showed increased urinary phosphate excretion and renal tubular dysfunction, which ameliorated with recovery from Legionella pneumonia. Serum fibroblast growth factor-23 level was suppressed, whereas serum 1,25(OH)2 vitamin D and parathyroid hormone levels were normal. Delayed elevation of serum 1,25(OH)2 vitamin D levels was observed with improvement in renal tubular function. These findings suggested hypophosphatemia might be mediated by renal tubular dysfunction.
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