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Related Concept Videos

Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

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The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
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Behavioral Genetics and Its Designs01:23

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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

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Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
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Related Experiment Video

Updated: Mar 22, 2026

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
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Welcome to Neurology: Genetics.

Stefan M Pulst1

  • 1Department of Neurology, University of Utah, Salt Lake City, UT.

Neurology. Genetics
|April 12, 2016
PubMed
Summary

Human genetics and technology are revolutionizing neurology. The field now embraces complex genetic variations, including risk-increasing DNA variants and unknown significance, moving beyond simple cause-and-effect.

Area of Science:

  • Neuroscience
  • Human Genetics
  • Genomic Medicine

Background:

  • Human genetics and advanced genetic technologies are reshaping neurology and neuroscience.
  • The understanding of genetic variation in neurological disorders has evolved from binary classifications to a complex spectrum.

Purpose of the Study:

  • To explore the transformative impact of human genetics on neurology and neuroscience.
  • To highlight the shift towards understanding nuanced genetic variations and their clinical significance.

Main Methods:

  • Review of current literature on genetic variation in neurological diseases.
  • Analysis of the implications of DNA variants, epigenetic modifications, and variants of unknown significance.

Main Results:

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  • A move from simple genetic determinism to a complex understanding of risk-associated DNA variants.
  • Recognition of epigenetic modifications playing a role in neurological conditions.
  • Identification of a significant number of variants with unknown or potentially pathogenic significance.

Conclusions:

  • The field of neurology is increasingly influenced by complex genetic insights.
  • Loss-of-function alleles and gene knockouts can be compatible with normal phenotypes for certain genes.
  • Future research must address the complexity of genetic variation in neurological disorders.