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Determination of high-sensitivity cardiac troponin I 99th percentile upper reference limits in a healthy Korean

Misuk Ji1, Hee-Won Moon1, Mina Hur1

  • 1Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, South Korea.

Clinical Biochemistry
|April 13, 2016
PubMed

Insights

This study established the 99th percentile upper reference limit for cardiac troponin I (cTnI) in a Korean population. Results show lower cTnI levels compared to other ethnicities, influenced by age and selection criteria.

Area of Science:

  • Cardiology
  • Clinical Chemistry
  • Population Health

Background:

  • Establishing accurate reference ranges for cardiac troponin I (cTnI) is crucial for diagnosing myocardial infarction.
  • High-sensitivity assays have improved detection limits, necessitating updated reference values.
  • Population-specific reference limits are important due to potential ethnic and demographic variations.

Purpose of the Study:

  • To determine the 99th percentile upper reference limit (URL) for cardiac troponin I (cTnI) using a high-sensitivity assay in a healthy Korean population.
  • To investigate the influence of age and sex on cTnI levels within this reference population.

Main Methods:

  • Enrolled 854 healthy Korean males and females (mean age 49.8 years).
  • Excluded participants with subclinical conditions based on estimated glomerular filtration rate, glycated hemoglobin, and B-type natriuretic peptide levels.
  • Measured serum cTnI using the ARCHITECT STAT High-Sensitive Troponin-I Assay.

Main Results:

  • The 99th percentile URL for cTnI in the Korean population was 18 ng/L (90% CI, 14-35 ng/L).
  • Specific 99th percentile URLs were 20 ng/L for males and 19 ng/L for females.
  • Median cTnI concentrations were higher in participants aged 50 years and older compared to younger individuals.

Conclusions:

  • The Korean reference population exhibited lower 99th percentile URLs for cTnI compared to other ethnic groups.
  • Factors such as ethnicity, age distribution, and health selection criteria significantly influence cTnI reference limits.
  • These findings underscore the importance of population-specific reference ranges for cTnI assays.
Abstract

Keywords:
99th percentileHigh-sensitivityReference populationTroponin-I

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