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Harnessing the Bioorthogonal Inverse Electron Demand Diels-Alder Cycloaddition for Pretargeted PET Imaging

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Nuclear and optical dual-labelled imaging agents. Design and challenges.

G Singh, M D Gott, H-J Pietzsch

¹Dr. rer. nat. Holger Stephan, Bautzner Landstraße 400, 01328 Dresden, Tel. +49/(0)351/260-30 91, Fax -32 32, h.stephan@hzdr.de.

Nuklearmedizin. Nuclear Medicine

|April 13, 2016

Summary

Dual-labelled molecular imaging agents combine nuclear and optical techniques for enhanced cancer detection and treatment monitoring. This approach offers improved visualization of tumors and metastases, aiding in diagnosis and surgical guidance.

Keywords:

Molecular imaging PET SPECT dual labelling fluorescence

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Published on: November 20, 2018

Area of Science:

Biomedical Imaging
Molecular Imaging
Nanotechnology

Background:

Molecular imaging visualizes biochemical processes at the molecular level.
Dual-labelled modalities like nuclear imaging (PET, SPECT) and near-infrared fluorescence (NIRF) offer high detection sensitivity.
Novel materials are crucial for developing non-invasive diagnostic and therapeutic monitoring strategies.

Purpose of the Study:

To review the development of dual-labelled agents for bimodal nuclear/optical imaging.
To highlight their application in cancer medicine for tumor detection and image-guided surgery.
To discuss various designs including modular ligands and nanoscale systems.

Main Methods:

Combining radionuclides and fluorescent dyes in imaging agents.
Utilizing modular ligands for agent design.
Developing nanoscale systems such as antibodies and their fragments.

Main Results:

Dual-labelled agents show promise for combined nuclear and optical imaging.
These agents facilitate tracking of tumors and metastases.
The combination enables image-guided surgery for improved tumor resection.

Conclusions:

Bimodal nuclear/optical imaging agents represent a significant advancement in molecular imaging.
They offer a powerful tool for early cancer diagnosis and treatment monitoring.
Further development of these agents, including nanoscale systems, is crucial for clinical translation.