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Related Experiment Video

Updated: Mar 22, 2026

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
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Pediatric posttraumatic endophthalmitis.

Haixiang Wu1,2, Xinyi Ding3, Meng Zhang3

  • 1Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China. whx577@163.com.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|April 13, 2016
PubMed
Summary
This summary is machine-generated.

Pediatric endophthalmitis, often caused by penetrating trauma, showed poor visual outcomes despite prompt vitrectomy. Staphylococci and Streptococcus were common culprits, with multiple organisms leading to worse recovery.

Keywords:
EndophthalmitisOcular traumaPediatricsVitrectomy

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Area of Science:

  • Ophthalmology
  • Microbiology
  • Pediatric Medicine

Background:

  • Endophthalmitis is a severe intraocular infection requiring prompt diagnosis and treatment.
  • Pediatric endophthalmitis presents unique challenges due to the age group and potential impact on visual development.

Purpose of the Study:

  • To determine the causes, treatment outcomes, and visual results of endophthalmitis in pediatric patients.
  • To analyze the microbiological findings and their correlation with visual prognosis in pediatric endophthalmitis.

Main Methods:

  • A consecutive series of 15 pediatric patients with endophthalmitis were treated with pars plana vitrectomy and intravitreal antibiotics (vancomycin and ceftazidime).
  • Vitreous samples were collected for Gram staining, culture, and sensitivity testing to identify causative organisms.
  • Patients were followed up for a mean of 9.7 months to assess visual outcomes.

Main Results:

  • Penetrating ocular trauma was the most frequent etiology.
  • Staphylococci and Streptococcus species were the most common microorganisms identified in cultures (66.7% positive).
  • Postoperative visual acuity was 20/200 or better in 40% of patients; however, 6.7% experienced no light perception.

Conclusions:

  • Penetrating trauma is a leading cause of endophthalmitis in children.
  • The presence of multiple organisms in cultures was associated with significantly poorer visual recovery.
  • Despite immediate surgical intervention, visual outcomes in this pediatric cohort were generally unfavorable.