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The role of the HGF/Met axis in mesothelioma

Thivyan Thayaparan1, James F Spicer2, John Maher3

  • 1King's College London, King's Health Partners Integrated Cancer Centre, Department of Research Oncology, Guy's Hospital Campus, Great Maze Pond, London SE1 9RT, U.K. Thivyan.t.thayaparan@kcl.ac.uk.

Biochemical Society Transactions
|April 13, 2016
PubMed

Insights

Malignant mesothelioma, an incurable asbestos-related cancer, involves aberrant signaling of receptor tyrosine kinases (RTKs). The hepatocyte growth factor (HGF)/Met pathway is frequently dysregulated, offering therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Malignant mesothelioma is an incurable asbestos-related cancer primarily affecting the pleural space.
  • Receptor tyrosine kinase (RTK)-directed signaling is increasingly implicated in mesothelioma pathogenesis.
  • Aberrant signaling of the Met receptor tyrosine kinase, activated by hepatocyte growth factor (HGF), is common in mesothelioma.

Purpose of the Study:

  • To describe the HGF/Met signaling axis.
  • To review mechanisms of aberrant HGF/Met activation in mesothelioma.
  • To explore therapeutic strategies targeting the HGF/Met pathway and its interactions.

Main Methods:

  • Review of existing literature on HGF/Met signaling in mesothelioma.
  • Analysis of mechanisms leading to aberrant HGF/Met activation.
  • Examination of cross-talk between HGF/Met and other signaling pathways.

Main Results:

  • The HGF/Met axis promotes cell survival, proliferation, movement, invasiveness, and angiogenesis.
  • Dysregulation of the HGF/Met pathway is prevalent in mesothelioma.
  • Significant cross-talk exists between HGF/Met and other receptor/ligand systems.

Conclusions:

  • Aberrant HGF/Met signaling is a key driver in malignant mesothelioma.
  • Targeting the HGF/Met axis presents a promising therapeutic avenue.
  • Combinatorial strategies targeting HGF/Met and related pathways may advance treatment for mesothelioma.
Keywords:
Methepatocyte growth factormalignant mesotheliomareceptor tyrosine kinasescatter factor

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