Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients.

Cell reports·2025

Same author

GLUT5 armouring enhances adoptive T-cell therapy anti-tumour activity under glucose-limiting conditions.

Immunotherapy advances·2025

Same author

Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma.

Journal for immunotherapy of cancer·2025

Same author

Conserved allomorphs of MR1 drive the specificity of MR1-restricted TCRs.

Frontiers in oncology·2024

Same author

Lifileucel, an Autologous Tumor-Infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non-Small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors.

Cancer discovery·2024

Same author

Pre-treatment with systemic agents for advanced NSCLC elicits changes in the phenotype of autologous T cell therapy products.

Molecular therapy oncolytics·2023

Search research articles

Related Experiment Video

Updated: Mar 22, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Dynamic imaging for CAR-T-cell therapy.

Nia Emami-Shahri¹, Sophie Papa²

¹ImmunoEngineering Group, Division of Cancer Studies, King's College London, London SE1 9RT, U.K.

Biochemical Society Transactions

|April 13, 2016

Summary

This summary is machine-generated.

Reporter gene imaging allows tracking of Chimaeric Antigen Receptor (CAR)-T-cells in vivo. This method aids in understanding CAR T-cell therapy successes and challenges for future clinical applications.

Keywords:

CAR-T-cells PET-CT SPECT-CT dynamic imaging reporter genes

More Related Videos

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Published on: October 27, 2023

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells

Published on: February 2, 2013

Related Experiment Videos

Last Updated: Mar 22, 2026

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Published on: October 27, 2023

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells

Quantitative High-throughput Single-cell Cytotoxicity Assay For T Cells

Published on: February 2, 2013

Area of Science:

Immunotherapy
Oncology
Medical Imaging

Background:

Chimaeric Antigen Receptor (CAR) T-cell therapy is a promising treatment for CD19(+) cancers.
Challenges remain in translating CAR T-cell therapy for solid tumors.
Understanding CAR T-cell behavior in vivo is crucial for clinical success.

Purpose of the Study:

To explore the utility of reporter gene imaging for tracking CAR T-cells.
To assess the feasibility of using clinically available tracers for CAR T-cell monitoring.

Main Methods:

Utilizing reporter gene imaging systems to detect and track adoptively transferred CAR T-cells.
Evaluating the compatibility of reporter gene systems with routine clinical tracers.

Main Results:

Reporter gene imaging enables detection and tracking of small numbers of CAR T-cells post-transfer.
The compatibility of certain reporter gene systems with clinical tracers enhances applicability.

Conclusions:

Reporter gene imaging is a valuable tool for monitoring CAR T-cell therapy in vivo.
This imaging approach can facilitate the clinical appraisal of CAR T-cell efficacy and safety.