Related Experiment Video

Updated: Mar 22, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

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315

Novel targets and interaction partners of mutant p53 Gain-Of-Function

Lydia Aschauer1, Patricia A J Muller2

  • 1MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, U.K.

Biochemical Society Transactions
|April 13, 2016
PubMed

Insights

Mutant p53 proteins gain tumor-promoting functions, driving cancer progression and chemo-resistance. This review details these gain-of-function (GOF) mechanisms, focusing on how mutant p53 hijacks transcription factors.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Loss or mutation of p53 is common in human cancers.
  • Mutant p53 proteins often gain oncogenic functions beyond wild-type p53 loss.

Purpose of the Study:

  • To review recent research on p53 gain-of-function (GOF) mechanisms.
  • To categorize p53 GOFs according to the hallmarks of cancer.

Main Methods:

  • Literature review of studies on mutant p53.
  • Analysis of p53 GOF mechanisms and their link to cancer hallmarks.

Main Results:

  • Mutant p53 GOFs promote tumorigenesis, chemo-resistance, invasion, and metastasis.
  • Many GOFs involve mutant p53 interacting with and hijacking other transcription factors.

Conclusions:

  • Mutant p53 GOFs represent a significant driver of cancer progression.
  • Understanding these mechanisms is crucial for developing targeted cancer therapies.
Keywords:
Gain-Of-Functionhallmarks of cancermutant p53

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