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A computer program in BASIC for estimation of ED50 and LD50.

¹Department of Paediatrics, National University of Singapore, Republic of Singapore.

Computers in Biology and Medicine

|January 1, 1989

Summary

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This study presents a BASIC computer program for calculating median effective dose (ED50) and median lethal dose (LD50) values. The program utilizes probit analysis and weighted linear regression, offering confidence limits and model validation.

Area of Science:

Pharmacology
Toxicology
Biostatistics

Background:

Accurate calculation of median effective dose (ED50) and median lethal dose (LD50) is crucial in pharmacology and toxicology.
Probit analysis and weighted linear regression are standard statistical methods for dose-response assessments.
Existing computational tools may lack user-friendliness or specific functionalities.

Purpose of the Study:

To develop a user-friendly BASIC computer program for calculating ED50 and LD50 values.
To incorporate confidence limit calculations and model validation using Chi-square analysis.
To provide a portable and adaptable software solution for dose-response analysis.

Main Methods:

The program employs probit analysis and weighted linear regression for dose-response curve fitting.

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It includes the Chi-square test for assessing the goodness-of-fit of the probit model.

High-resolution graphic display capabilities are integrated for data visualization.

Main Results:

The developed program accurately calculates ED50 and LD50 values with associated confidence intervals.
The Chi-square procedure validates the underlying mathematical model's suitability.
The software provides clear graphical representations of the dose-response data.

Conclusions:

The BASIC program offers a reliable and accessible tool for determining ED50 and LD50.
Its portability and modifiability facilitate its use across various microcomputer platforms.
This tool aids researchers in conducting robust dose-response analyses in toxicological and pharmacological studies.