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Related Experiment Videos

Delayed patch test reactions at days 7 and 9.

A W Macfarlane1, R K Curley, R M Graham

  • 1University Department of Dermatology, Royal Liverpool Hospital, UK.

Contact Dermatitis
|February 1, 1989
PubMed
Summary
This summary is machine-generated.

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Late positive patch test reactions, occurring after day 4, were observed in 7.2% of patients. Readings on days 4 and 7 proved most reliable for diagnosing allergic contact dermatitis.

Area of Science:

  • Dermatology
  • Allergology
  • Immunology

Background:

  • Patch testing is crucial for diagnosing allergic contact dermatitis.
  • Understanding the timing and reliability of patch test reactions is essential for accurate diagnosis.

Purpose of the Study:

  • To evaluate the incidence and characteristics of late positive patch test reactions.
  • To determine the optimal timing for patch test readings to ensure reliability.

Main Methods:

  • 403 consecutive patients underwent patch testing with readings on days 2, 4, 7, and 9.
  • Late positive reactions were defined as those appearing after day 4.
  • Retesting was performed in a subset of patients to assess sensitization.

Main Results:

Related Experiment Videos

  • Late positive reactions were observed in 7.2% of patients.
  • Neomycin, potassium dichromate, and cobalt were common causes of late reactions.
  • Paired readings on days 4 and 7 were more reliable than earlier readings.
  • A single reading on day 4 was deemed most informative.
  • Day 9 readings offered limited additional value.

Conclusions:

  • Late positive patch test reactions can occur and are associated with specific allergens.
  • Patch test readings on days 4 and 7 provide the most reliable diagnostic information.
  • A single day 4 reading may be sufficient in some cases, while day 9 readings have minimal utility.