Natural polyphenols: Influence on membrane transporters

Area of Science:

• Nutritional biochemistry
• Pharmacology
• Molecular biology

Background:

• Polyphenols are natural compounds with diverse bioactivities, offering protection against age-related diseases.
• Polyphenols interact with transporter proteins, including efflux transporters like P-glycoprotein, affecting drug resistance.
• Limited research exists on polyphenol interactions with uptake transporters.

Purpose of the Study:

• To review the potential of polyphenols in modulating uptake transporter proteins.
• To explore the influence of polyphenols on neurotransmitter transporter activity.
• To assess the implications for neuropharmacology.

Main Methods:

• Literature review of existing studies on polyphenol-transporter interactions.
• Analysis of data concerning polyphenol effects on efflux and uptake transporters.
• Synthesis of information on dietary polyphenol-drug interactions.

Main Results:

• Polyphenols can modulate efflux transporters, potentially enhancing anticancer and antiviral drug efficacy.
• Polyphenols may influence drug efficacy through food-drug interactions.
• Further investigation is needed on polyphenol effects on uptake transporters.

Conclusions:

• Polyphenols show promise in modulating drug resistance and efficacy.
• Understanding polyphenol interactions with uptake transporters is crucial for neuropharmacology.
• Dietary polyphenols can significantly impact drug action.