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Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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Reprogramming cancer cells: overview & current progress

Kian Lam Lim1, Hoon Koon Teoh1,2, Pei Feng Choong1,2

  • 1a Faculty of Medicine and Health Sciences , Universiti Tunku Abdul Rahman , Sungai Long , Selangor 43000 , Malaysia.

Expert Opinion on Biological Therapy
|April 13, 2016
PubMed
Abstract

Insights

Reprogramming cancer cells with transcription factors can alter their characteristics, offering potential for new cancer disease models and personalized therapies. This technology aids in studying cancer origins and screening drugs.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Epigenetics

Background:

  • Cancer arises from genetic and epigenetic alterations.
  • Reprogramming cancer cells using transcription factors is an emerging field.
  • Few studies have successfully reprogrammed malignant human cells into induced pluripotent stem cells (iPSCs).

Purpose of the Study:

  • To review methods for reprogramming cancer cells.
  • To discuss the characterization of reprogrammed cancer cells.
  • To explore the effects of reprogramming on cancer malignancy, epigenetics, and drug response.

Main Methods:

  • Overview of various techniques used for cancer cell reprogramming.
  • Analysis of methods for characterizing reprogrammed cancer cells.
  • Examination of studies investigating the impact of reprogramming on cancer cell properties.

Main Results:

  • Reprogramming can alter cancer cell characteristics compared to parental cells.
  • Successful reprogramming of malignant human cells is challenging but achievable.
  • Reprogramming impacts cancer cell malignancy, epigenetics, and chemosensitivity.

Conclusions:

  • Cancer cell reprogramming holds promise for creating advanced in vitro disease models.
  • Further technical advancements are crucial for refining reprogramming technologies.
  • This technology may lead to the development of directed and personalized cancer therapies.
Keywords:
iPCiPSCpluripotentreprogramming cancer cellsstem cells

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