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Updated: Mar 22, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Feasibility of Using Information Derived from a Care Partner to Develop a Frailty Index Based on Comprehensive
J Goldstein1, R E Hubbard, P Moorhouse
1Judah Goldstein, Dalhousie Division of Geriatric Medicine, Veteran Memorial Building, 1421- 5955 Veterans Memorial Lane, Halifax, Nova Scotia, Canada B3H 2E1, Tel: 902-473-4994, Fax: 902-473-1050,
Background:
Frailty is a state of increasing vulnerability that places an individual at high risk for adverse health outcomes. The best approach for frailty measurement in clinical practice has not been resolved. Frailty can be measured by deficit accumulation and be derived from a comprehensive geriatric assessment (CGA). In busy clinical practice, it may not be feasible to gather this information entirely from patients, particularly from those with cognitive decline.
Objective:
We describe the feasibility of a frailty index based upon a care partner derived CGA (CP-CGA). In addition, we sought to establish the acceptability of the questionnaire and explore whether care partners felt that the provided information contribute to patient assessment.
Design And Setting:
A cross-sectional data analysis of 99 community dwelling older adults attending geriatric ambulatory care clinics at a single tertiary care center.
Measurements:
Care partners completed the CP-CGA and a Clinical Frailty Scale (CFS; Range 1 -Very fit- to 9 -Terminally ill). We evaluated the time to complete and item completeness.
Results:
The mean age of patients was 81.3±5.7 years. Most were women (n=54), widowed, lived in their own home, with a median CFS of 5 (Mildly Frail). The care partner respondent was usually an offspring. Item completeness was 95% with a mean time to complete of 15.5±8.6 minutes.
Conclusion:
The CP-CGA seems feasible for gathering information that would be integral towards determining frailty by deficit accumulation. Future inquiries will evaluate its feasibility in other settings and validity as a form of frailty assessment.
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