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Klotho, FGF21 and FGF23: Novel Pathways to Musculoskeletal Health?
B Bartali1, R D Semba, A B Araujo
1Benedetta Bartali, PhD, New England Research Institutes, 9 Galen Street Watertown, MA 02472 USA, Phone: +1(617) 972-3350, FAX: +1 (617) 673-9514,
The Journal of Frailty & Aging
|April 13, 2016
Summary
Aging causes declines in bone density and muscle mass. This review explores how biomarkers like klotho and fibroblast growth factors (FGFs) may influence musculoskeletal aging, suggesting new research directions.
Area of Science:
- Gerontology
- Biochemistry
- Musculoskeletal Health
Background:
- Bone mineral density, muscle mass, and physical function peak in early adulthood.
- These parameters experience a steady decline with advancing age.
Purpose of the Study:
- To propose a theoretical framework for the role of emerging biomarkers in musculoskeletal aging.
- To investigate the potential influence of klotho, FGF21, and FGF23 on age-related decline in muscle mass and function.
Main Methods:
- Mini-review of existing literature.
- Theoretical framework development.
- Identification of potential physiological mechanisms.
Main Results:
- Emerging biomarkers klotho, FGF21, and FGF23 are proposed as modulators of musculoskeletal health during aging.
- A link between these biomarkers and the decline in muscle mass and function is hypothesized.
Conclusions:
- Understanding the physiological roles of klotho and FGFs in aging may reveal novel intervention targets.
- Further research is warranted to validate the proposed link and explore therapeutic strategies.
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