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The (Patho)physiology of Fibrinogen γ'
Fraser L Macrae1, Marco M Domingues1, Alessandro Casini1
1Thrombosis and Tissue Repair Group, Division of Cardiovascular and Diabetes Research, Leeds Institute of Cardiovascular and Metabolic Medicine, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom.
Seminars in Thrombosis and Hemostasis
|April 13, 2016
Summary
Fibrinogen γ
Area of Science:
- Biochemistry
- Hematology
- Molecular Biology
Background:
- Fibrinogen γ' is a splice variant of the fibrinogen γ-chain.
- It results in a negatively charged C-terminal extension.
- It primarily exists as a γA/γ' fibrinogen heterodimer.
Purpose of the Study:
- To provide an updated summary of the biological aspects of fibrinogen γ'.
- To discuss inconsistencies in current reports regarding this variant.
- To highlight its potential role in thrombosis.
Main Methods:
- Literature review of existing studies on fibrinogen γ'.
- Analysis of functional effects on thrombin and FXIII.
- Examination of clinical associations with thrombotic events.
Main Results:
- Fibrinogen γ' modulates thrombin and FXIII activity.
- It influences fibrin clot architecture.
- It lacks a platelet-binding site and is associated with thromboses.
Conclusions:
- Fibrinogen γ' has significant functional effects.
- Its presence in all individuals and association with thrombosis warrant further investigation.
- Understanding this variant is crucial for thrombosis research.
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