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FRET Microscopy for Real-time Monitoring of Signaling Events in Live Cells Using Unimolecular Biosensors
Published on: August 20, 2012
Nanocommunication via FRET With DyLight Dyes Using Multiple Donors and Acceptors
Abstract:
The phenomenon of Förster Resonance Energy Transfer, commonly used to measure the distances between fluorophore molecules and to study interactions between fluorescent-tagged proteins in life sciences, can also be applied in nanocommunication networks to transfer information bits. The mechanism offers a relatively large throughput and very small delays, but at the same time the channel bit error rate is too high and the transmission ranges are too limited for communication purposes. In this paper, multiple donors at the transmitter side and multiple acceptors at the receiver side are considered to decrease the bit error rate. As nanoantennas, the DyLight fluorescent dyes, which are very well suited to long range nanocommunication due to their large Förster distances and high degrees of labeling, are proposed. The reported results of the recent laboratory experiments confirm efficient communication on distances over 10 nm.

