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Updated: Mar 22, 2026

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Second-hand smoke exposure generated by new electronic devices (IQOS® and e-cigs) and traditional cigarettes:
C Protano1, M Manigrasso2, P Avino2
1Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy.
Abstract:
Passive exposure profiles to submicronic particles (SMPs, 5.6-560 nm) of traditional cigarettes and new electronic commercial devices (e-cig and IQOS®, a new heat-not-burn smoking device) were compared. During smoking, SMPs released by traditional cigarettes resulted four-times higher than those released by electronic and heat-not-burn devices and remained high for at least one hour, while SMPs values returned immediately similar to background for electronic and heat-not-burn devices. In all experiments, approximately half of SMPs resulted so small to reach the alveolar region.
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