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Nonintercalative binding of ethidium bromide to nucleic acids: crystal structure of an ethidium--tRNA molecular
Abstract:
X-ray diffraction studies at 4.5-A resolution on crystals of a complex of ethidium bromide and yeast phenylalanine tRNA reveal a nonintercalative model of binding of the ethidium within the tertiary structure. This is contrary to the expected interacalative binding to the double-helical regions.