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Myocardial arterial spin labeling.

Frank Kober1, Terrence Jao2, Thomas Troalen3

  • 1Aix-Marseille Université, CNRS CRMBM UMR 7339, Centre de Résonance Magnétique Biologique et Médicale, Marseille, France. frank.kober@univ-amu.fr.

Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance
|April 14, 2016
PubMed
Summary
This summary is machine-generated.

Arterial spin labeling (ASL) cardiovascular magnetic resonance (CMR) maps blood flow without contrast agents. Research is advancing ASL-CMR for human and large animal applications, overcoming past sensitivity limitations.

Keywords:
Arterial spin labelingCardiovascular magnetic resonanceIschemic heart diseaseMyocardial perfusion

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Medical Imaging Techniques
  • Hemodynamics

Background:

  • Arterial spin labeling (ASL) is a non-contrast cardiovascular magnetic resonance (CMR) technique for assessing myocardial blood flow.
  • ASL-CMR offers advantages like stress compatibility and repeated/continuous monitoring.
  • While successful in small animals, ASL-CMR sensitivity in humans and large animals has been a significant research challenge.

Purpose of the Study:

  • To review the evolution of ASL-CMR techniques.
  • To summarize current state-of-the-art imaging methods and recent findings.
  • To discuss future research directions and the influence of brain and small-animal ASL-CMR.

Main Methods:

  • Comprehensive literature review of ASL-CMR development.
  • Analysis of pre-clinical and clinical study findings.
  • Exploration of technological advancements and their impact.

Main Results:

  • ASL-CMR has shown promise but faces sensitivity limitations in human and large animal studies.
  • Progress in brain ASL and small-animal ASL-CMR has provided valuable insights.
  • Ongoing research focuses on improving sensitivity and clinical applicability.

Conclusions:

  • Arterial spin labeling cardiovascular magnetic resonance is a developing field with significant potential.
  • Overcoming sensitivity challenges is key to widespread clinical adoption in humans and large animals.
  • Continued research, informed by existing ASL applications, is crucial for future advancements.