Related Experiment Video
Updated: Aug 18, 2026

A Model of Self-limited Acute Lung Injury by Unilateral Intra-bronchial Acid Instillation
Published on: August 30, 2019
Furnace-generated acid aerosols: speciation and pulmonary effects
1Department of Applied Biological Science, Massachusetts Institute of Technology, Cambridge 02139.
Abstract:
Guinea pigs were exposed to ultrafine aerosols (less than 0.1 micron) of zinc oxide with a surface layer of sulfuric acid. These acid-coated aerosols are typical of primary emissions from smelters and coal combustors. Repeated daily 3-hr exposures for 5 days produce decrements in lung volumes and pulmonary diffusing capacity and elevations of lung weight/body weight ratio, protein, and number of neutrophils in pulmonary lavage fluid at concentrations of 20 micrograms/m3. A single 1-hr exposure to 20 micrograms/m3 causes increased bronchial reactivity. Higher concentrations of conventionally generated sulfuric acid mist are required to produce responses of similar magnitude.
More Related Videos
08:33Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies
Published on: April 12, 2022
09:29An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
Related Concept Videos
Atomic Absorption Spectroscopy: Atomization Methods
Atomic Emission Spectroscopy: Interference
Acid Mine Drainage
Inhalation Anthrax
Chronic Obstructive Pulmonary Disease II: Emphysema