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Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
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Authors' reply to Perry

Darrel P Francis1, Graham D Cole1

  • 1International Centre for Circulatory Health, National Heart and Lung Institute, Imperial College London, London W2 1LA, UK.

BMJ (Clinical Research Ed.)
|April 14, 2016
PubMed
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No abstract available in PubMed .

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