Related Experiment Video
Updated: Mar 22, 2026

Malachite Green Assay for the Discovery of Heat-Shock Protein 90 Inhibitors
Published on: January 20, 2023
Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright Future
1Hauptman-Woodward Medical Research Institute, 700 Ellicott Street, Buffalo, NY, 14203, USA. gewirth@hwi.buffalo.edu.
Background:
The high sequence and structural homology among the hsp90 paralogs - Hsp90α, Hsp90β, Grp94, and Trap-1 - has made the development of paralog-specific inhibitors a challenging proposition.
Objective:
This review surveys the state of developments in structural analysis, compound screening, and structure-based design that have been brought to bear on this problem.
Results:
First generation compounds that selectively bind to Hsp90, Grp94, or Trap-1 have been identified.
Conclusion:
With the proof of principle firmly established, the prospects for further progress are bright.
More Related Videos
06:51Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
Published on: July 21, 2021
09:39Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology
Published on: March 31, 2022
Related Concept Videos
Inhibitors of Viral Protein Synthesis
Targeted Cancer Therapies
There are several types of targeted therapies against...
Dipeptidyl Peptidase 4 Inhibitors
Inhibitors of Bacterial Protein Synthesis
Molecular Chaperones and Protein Folding
The...
Inhibitors of Bacterial DNA Synthesis