Related Experiment Video
Updated: Mar 22, 2026

Generic Protocol for Optimization of Heterologous Protein Production Using Automated Microbioreactor Technology
Published on: December 15, 2017
Metabolic engineering with systems biology tools to optimize production of prokaryotic secondary metabolites
Hyun Uk Kim1, Pep Charusanti, Sang Yup Lee
1BioInformatics Research Center, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea. ehukim@kaist.ac.kr.
Abstract:
Covering: 2012 to 2016Metabolic engineering using systems biology tools is increasingly applied to overproduce secondary metabolites for their potential industrial production. In this Highlight, recent relevant metabolic engineering studies are analyzed with emphasis on host selection and engineering approaches for the optimal production of various prokaryotic secondary metabolites: native versus heterologous hosts (e.g., Escherichia coli) and rational versus random approaches. This comparative analysis is followed by discussions on systems biology tools deployed in optimizing the production of secondary metabolites. The potential contributions of additional systems biology tools are also discussed in the context of current challenges encountered during optimization of secondary metabolite production.
More Related Videos
Related Concept Videos
Bioreactor Controls-III
Production of Antibiotics
Biosynthesis in Bacteria
Upstream Processing
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Production of Pharmaceuticals

