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Updated: Mar 22, 2026

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
Variable effect of maternal oral glucose load on circulating cell-free placental mRNAs
Teresa Mary MacDonald1,2,3, Tu'uhevaha Joy Kaitu'u-Lino1,2, Susan Philippa Walker2,3
1a Translational Obstetrics Group, Mercy Hospital for Women , Melbourne , Heidelberg , Australia.
Background:
It is not known whether fasting affects levels of circulating placenta-specific transcripts.
Objective:
To assess whether a glucose load affects circulating placenta-specific transcripts.
Method:
RNA was extracted from paired blood samples (fasting and 1-h post 75 g oral glucose) from 22 women. Placenta-specific genes were measured by RT-qPCR.
Results:
There was no change in ADM, CSH1, PAPPA2, PSG1 or TAC3 expression between fasting and post-glucose states. However, HTRA1 decreased after glucose load.
Conclusion:
Maternal fasting state does not influence expression of the majority of placenta-specific genes but may need to be accounted for when validating biomarkers of placental disease.
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