Oxidative stress markers in laparoscopic vs. open appendectomy for acute appendicitis: A double-blind randomized...

Area of Science:

• Biochemistry
• Surgical Innovation
• Inflammation Research

Background:

• Oxidative stress, an imbalance of prooxidants and antioxidants, is linked to inflammation and surgical trauma.
• Previous studies indicate a connection between acute appendicitis and oxidative stress.
• The comparative impact of laparoscopic appendectomy (LA) versus open appendectomy (OA) on oxidative stress remains unclear.

Purpose of the Study:

• To compare the levels of oxidative stress markers following LA and OA in patients with acute appendicitis.
• To investigate the potential role of oxidative stress reduction in the advantages of LA.

Main Methods:

• A randomized clinical trial involving 100 patients with acute appendicitis (50 LA, 50 OA).
• Blood samples were collected pre-operatively and 24 hours post-operatively to measure total oxidant status (TOS), total antioxidant status (TAS), C-reactive protein (CRP), and white blood cells (WBCs).
• Oxidative Stress Index (OSI) was calculated.

Main Results:

• Postoperative CRP levels were significantly lower in the LA group compared to the OA group (P=0.031).
• Postoperative TOS and OSI were significantly higher in the OA group than in the LA group (P=0.017 and P=0.002, respectively).
• No significant differences were observed in preoperative markers or postoperative TAS between the two groups.

Conclusions:

• Laparoscopic appendectomy is associated with significantly reduced oxidative stress compared to open appendectomy for uncomplicated appendicitis.
• The observed benefits of LA may be partly attributed to its ability to lower oxidative stress.
• This study provides evidence supporting LA as a potentially less stressful surgical option regarding oxidative damage.