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Published on: August 15, 2025
Primary intraosseous squamous cell carcinoma derived from a maxillary cyst: A case report and literature review
Takuma Morita1, Masashi Yamashiro2, Kou Kayamori3
1Division of Maxillofacial and Neck Reconstruction, Department of Maxillofacial Reconstruction and Function, Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo 113-8549, Japan.
Abstract:
Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare malignant central jaw tumor derived from odontogenic epithelial remnants. PIOSCC predominantly affects the mandible, although both jawbones may be involved. This case report describes a PIOSCC type 2 of the maxilla in a 37-year-old man, treated by partial maxillectomy. Histopathologically, the tumor was diagnosed as PIOSCC derived from an odontogenic cyst. Postoperatively, the patient has been followed up for 53 months, with no recurrence of the disease. We herein describe the clinical details, treatment results and histopathological characteristics of a rare case of PIOSCC derived from a maxillary odontogenic cyst with reference to the relevant literature.

