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Updated: Mar 22, 2026
Creation of Abdominal Adhesions in Mice
Published on: August 27, 2016
Effect of ankaferd blood stopper in experimental peritoneal adhesion model
Gokhan Karaca1, Oktay Aydin1, Faruk Pehlivanli1
1Department of General Surgery, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
Purpose:
Ankaferd Blood Stopper (ABS) is an herbal extract attained from 5 different plants. It has the therapeutic potential to be used for the management of external hemorrhage and controlling gastrointestinal bleedings. To date, the safety of ABS for intraperitoneal usage is not clear. In this study, we investigated the effectiveness and safety of using intraperitoneal ABS in an experimental peritoneal adhesion model.
Methods:
Twenty-four male Wistar Albino rats were used in the study. The rats were randomly divided into 3 groups: saline, ABS, and control. On the 10th day, all rats were euthanized. The adhesions were evaluated by Nair's macroscopic adhesion classification, and pathologically evaluated with Zühlke's microscopic adhesion classification.
Results:
macroscopic and microscopic comparison between the ABS and saline groups did not show any differences but both the ABS and saline groups were superior when compared to the control group.
Conclusion:
ABS was found equally effective with saline on the abdominal adhesions and to no effect on postoperative adhesion formation.
