Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Lethal extrapulmonary mycobacteriosis.

S Kos¹, J Důra, J Jirásek

¹Department of Tuberculosis and Respiratory Diseases, Faculty Hospital, Plzen, Czechoslovakia.

The European Respiratory Journal

|January 1, 1989

Summary

A previously healthy man died from disseminated extrapulmonary mycobacteriosis caused by Mycobacterium kansasii. This rare condition rapidly affected multiple organs without lung involvement.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Measurement of anti-TSH receptor antibodies: what is the correct cut-off value?

The Netherlands journal of medicine·2020

Same author

IGF-1 and IGF-1 SDS - fit for purpose?

European journal of endocrinology·2019

Same author

Optimization of laboratory procedures for intrauterine insemination: survey of methods in relation to clinical outcome.

Andrology·2018

Same author

Techniques used for IUI: is it time for a change?

Human reproduction (Oxford, England)·2017

Same author

Communication: XUV transient absorption spectroscopy of iodomethane and iodobenzene photodissociation.

The Journal of chemical physics·2016

Same author

Displacement of malignant cells into the portal triad of the liver results in reduced liver perfusion, mimicking segmental Fatty liver.

Case reports in oncology·2013

Area of Science:

Infectious Diseases
Microbiology
Pathology

Background:

Tuberculosis (TB) typically affects the lungs, but extrapulmonary TB can occur.
Mycobacterium kansasii is an atypical mycobacterium that can cause disease in humans.
Disseminated extrapulmonary mycobacteriosis is a rare and severe manifestation of mycobacterial infection.

Observation:

A 60-year-old man presented with fever, rash, leukopenia, and gastrointestinal mycosis.
Despite prompt medical treatment, the patient experienced rapid deterioration and died within six weeks.
Autopsy revealed disseminated tuberculosis in lymph nodes, liver, spleen, and bone marrow, confirmed by acid-fast bacilli smears.

Findings:

Bacteriological examination isolated Mycobacterium kansasii from lymph node and spleen tissue.
Histological examination confirmed disseminated tuberculosis but found no evidence of primary lung tuberculosis.
The clinical presentation and autopsy findings led to a diagnosis of generalized extrapulmonary mycobacteriosis.

Implications:

This case highlights the potential for Mycobacterium kansasii to cause severe, rapidly progressive disseminated extrapulmonary disease.
It underscores the importance of considering atypical mycobacterial infections in immunocompetent individuals presenting with disseminated disease, even without apparent lung involvement.
Early diagnosis and appropriate antimicrobial therapy are crucial for managing this rare but potentially fatal condition.

Related Experiment Videos