Relationship Between Serum High-Sensitivity C-Reactive Protein and Myocardial Infarction in a General Japanese
Teruyuki Sugiyama1, Shizukiyo Ishikawa2, Kazuhiko Kotani1,3
1Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.
Journal of Clinical Laboratory Analysis
|April 15, 2016
Summary
High-sensitivity C-reactive protein (hsCRP) predicted myocardial infarction (MI) in Japanese men, but not women, due to lower baseline hsCRP levels. Further research is needed to explore hsCRP
Area of Science:
- Cardiology
- Biomarkers
- Epidemiology
Background:
- Serum high-sensitivity C-reactive protein (hsCRP) levels are lower in Japanese populations compared to Western populations.
- The clinical applicability of hsCRP for primary prevention of atherosclerotic events in Japanese individuals remains unclear.
- Investigating the association between hsCRP and myocardial infarction (MI) in general Japanese population is crucial.
Purpose of the Study:
- To investigate the relationship between serum hsCRP levels and the incidence of MI in a general Japanese population.
- To determine if hsCRP can serve as a predictive biomarker for MI in Japanese men and women.
Main Methods:
- A multiregional, population-based prospective cohort study.
- Involved 6,637 participants (mean age 54.9 years; 2,513 men/4,124 women).
- hsCRP levels were measured, and MI incidence was tracked over a 10.7-year follow-up period.
Main Results:
- Fifty-six MI cases were confirmed during the follow-up.
- Cut-off hsCRP levels for the highest quartile were 0.368 mg/l in men and 0.279 mg/l in women.
- The highest hsCRP quartile was associated with a significantly increased risk of MI in men (multivariate-adjusted HR: 2.07), but not in women (HR: 1.03).
Conclusions:
- Serum hsCRP measurement effectively predicted MI risk in Japanese men.
- hsCRP did not show significant predictive value for MI in Japanese women.
- Further exploration is needed to establish the applicability of hsCRP for MI risk assessment in Japanese populations with characteristically low hsCRP levels.
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