Relationship Between Serum High-Sensitivity C-Reactive Protein and Myocardial Infarction in a General Japanese
Teruyuki Sugiyama1, Shizukiyo Ishikawa2, Kazuhiko Kotani1,3
1Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Tochigi, Japan.
Insights
High-sensitivity C-reactive protein (hsCRP) predicted myocardial infarction (MI) in Japanese men, but not women, due to lower baseline hsCRP levels. Further research is needed to explore hsCRP
Area of Science:
- Cardiology
- Biomarkers
- Epidemiology
Background:
- Serum high-sensitivity C-reactive protein (hsCRP) levels are lower in Japanese populations compared to Western populations.
- The clinical applicability of hsCRP for primary prevention of atherosclerotic events in Japanese individuals remains unclear.
- Investigating the association between hsCRP and myocardial infarction (MI) in general Japanese population is crucial.
Purpose of the Study:
- To investigate the relationship between serum hsCRP levels and the incidence of MI in a general Japanese population.
- To determine if hsCRP can serve as a predictive biomarker for MI in Japanese men and women.
Main Methods:
- A multiregional, population-based prospective cohort study.
- Involved 6,637 participants (mean age 54.9 years; 2,513 men/4,124 women).
- hsCRP levels were measured, and MI incidence was tracked over a 10.7-year follow-up period.
Main Results:
- Fifty-six MI cases were confirmed during the follow-up.
- Cut-off hsCRP levels for the highest quartile were 0.368 mg/l in men and 0.279 mg/l in women.
- The highest hsCRP quartile was associated with a significantly increased risk of MI in men (multivariate-adjusted HR: 2.07), but not in women (HR: 1.03).
Conclusions:
- Serum hsCRP measurement effectively predicted MI risk in Japanese men.
- hsCRP did not show significant predictive value for MI in Japanese women.
- Further exploration is needed to establish the applicability of hsCRP for MI risk assessment in Japanese populations with characteristically low hsCRP levels.
Background:
Due to ethic differences in its serum levels, clinical applicability of high-sensitivity C-reactive protein (hsCRP) to the primary prevention of atherosclerotic events has not completely been established in Japanese people whose hsCRP levels are lower than in Western people. This study investigated the relationship between hsCRP and myocardial infarction (MI) in general Japanese people.
Methods:
In relation to hsCRP, the incidence of MI was determined in a multiregional population-based prospective cohort study (n = 6,637; mean age 54.9 years; 2,513 men/4,124 women).
Results:
Fifty-six cases of MI were confirmed during a follow-up period of 10.7 years. The cut-off levels of hsCRP between the highest quartile (fourth quartile) and the other quartiles combined were 0.368 mg/l in men and 0.279 mg/l in women. The hazard ratio (HR) of the highest quartile for MI was significantly greater than that of the other quartiles combined (multivariate-adjusted HR: 2.07, 95% confidence interval: 1.03-4.15) in men, but not in women (1.03, 0.35-2.21).
Conclusions:
In this population, serum hsCRP measurement predicted MI in men, but not in women. Under the low hsCRP level, a method of applicability of hsCRP to a risk assessment for preventing MI among Japanese people should be further explored.
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