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Protease Inhibitors Do Not Affect Antibody Responses to Pneumococcal Vaccination
Indhira De La Rosa1, Iona M Munjal2, Maria Rodriguez-Barradas1,3
1Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Abstract:
HIV(+) subjects on optimal antiretroviral therapy have persistently impaired antibody responses to pneumococcal vaccination. We explored the possibility that this effect may be due to HIV protease inhibitors (PIs). We found that in humans and mice, PIs do not affect antibody production in response to pneumococcal vaccination.
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