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Related Experiment Video

Updated: Mar 22, 2026

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
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Azapirones for Attention Deficit Hyperactivity Disorder: A Systematic Review.

Y Matsui1, S Matsunaga1, Y Matsuda1

  • 1Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan.

Pharmacopsychiatry
|April 15, 2016
PubMed
Summary
This summary is machine-generated.

This review found insufficient evidence to confirm buspirone as an effective treatment for attention deficit hyperactivity disorder (ADHD). Further research is needed to determine its clinical benefits for ADHD patients.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Clinical Psychology

Background:

  • Azapirones, specifically serotonin 1A receptor partial agonists, have not been extensively studied as anxiolytics for attention deficit hyperactivity disorder (ADHD).
  • Existing research on anxiolytics for ADHD primarily focuses on other drug classes.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the efficacy and safety of azapirones, particularly buspirone, as an anxiolytic treatment for ADHD.
  • To synthesize available evidence from randomized controlled trials (RCTs) and single-arm studies.

Main Methods:

  • A systematic search of major healthcare databases and clinical trial registries was performed for studies published before October 27, 2015.
  • Included were 5 RCTs and 3 single-arm studies involving buspirone in children, adolescents, and adults with ADHD.
  • Relative risk and 95% confidence intervals were calculated for relevant outcomes.

Main Results:

  • Pooled data from 3 RCTs showed no significant differences in all-cause discontinuation rates or adverse events between buspirone and methylphenidate.
  • Two RCTs found no significant differences in ADHD symptom scores (ADHD-Rating Scale) between buspirone and methylphenidate.
  • One RCT indicated methylphenidate showed superior improvement in ADHD symptom scores compared to buspirone.

Conclusions:

  • The current evidence is insufficient to establish the clinical benefit of buspirone for patients with ADHD.
  • Further high-quality research is required to determine the efficacy and safety of buspirone in the management of ADHD.