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Potential impacts of horizontal gene transfer on human health and physiology and how anthropogenic activity can affect it.

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Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants
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Accepting Foreign Genes.

Luis Boto1

  • 1Dpto. Biodiversidad y Biología Evolutiva, Museo Nacional de Ciencias Naturales (CSIC), C/José Gutierrez Abascal 2, 28006, Madrid, Spain. mcnb119@mncn.csic.es.

Journal of Molecular Evolution
|April 15, 2016
PubMed
Summary
This summary is machine-generated.

Host genomic background is crucial for stably maintaining horizontally acquired genes. Post-transfer modifications in both host and foreign genes facilitate their stable integration.

Keywords:
ContingencyEvolutionHorizontal gene transferIntegration of foreign genes

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Area of Science:

  • Genetics
  • Genomics
  • Molecular Biology

Background:

  • Horizontally acquired genes (HAGs) can be integrated into host genomes.
  • The stability of HAGs is influenced by various factors.

Discussion:

  • Three recent studies highlight the critical role of the host genomic background in HAG maintenance.
  • These papers suggest that evolutionary adaptations in both host and HAGs are necessary for stable integration.
  • This implies a co-evolutionary process between the host and acquired genetic material.

Key Insights:

  • The host's genetic makeup is a primary determinant for the long-term survival of foreign DNA.
  • Adaptations occurring after gene transfer are essential for successful integration and stability.
  • Both the host genome and the acquired genes undergo changes to ensure compatibility.

Outlook:

  • Further research can explore the specific molecular mechanisms driving these post-transfer adaptations.
  • Understanding these processes could have implications for synthetic biology and gene therapy.
  • Investigating HAG stability across diverse organisms will provide broader insights into genome evolution.