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The pattern of circulating microparticles in patients with diabetes mellitus with asymptomatic atherosclerosis

Alexander E Berezin1, Alexander A Kremzer2, Tatyana A Berezina3

  • 1a Internal Medicine Department , State Medical University , 26, Mayakovsky av., Zaporozhye 69035 , Ukraine.

Acta Clinica Belgica
|April 15, 2016
PubMed
Abstract

Insights

Microparticle (MP) patterns reveal accelerated atherosclerosis in type 2 diabetes mellitus (T2DM). Increased CD31+/annexin V+ MPs and decreased CD62E+ MPs are linked to asymptomatic coronary atherosclerosis in T2DM patients.

Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Biomarkers

Background:

  • Accelerated atherosclerosis in type 2 diabetes mellitus (T2DM) is linked to microparticle (MP) imbalance.
  • MPs are involved in vascular repair, inflammation, and thrombosis.

Purpose of the Study:

  • Investigate circulating MP patterns in T2DM patients with asymptomatic atherosclerosis.
  • Identify MP biomarkers associated with subclinical coronary artery disease in diabetes.

Main Methods:

  • 103 T2DM patients and 35 healthy volunteers were enrolled.
  • Contrast-enhanced multispiral computed tomography angiography assessed coronary atherosclerosis.
  • Flow cytometry characterized circulating MPs from blood samples.

Main Results:

  • T2DM patients showed lower CD62E+ and CD105E+ MPs, and higher CD31+/annexin V+ MPs than controls.
  • Increased CD41a+, CD144+/CD31+, CD31+/annexin V+ MPs and decreased CD62E+ MPs were found in T2DM with asymptomatic atherosclerosis.
  • BMI, LDL-C, hs-CRP, osteoprotegerin, CD62E+ MPs, and CD31+/annexin V+ MPs were independent predictors of atherosclerosis.

Conclusions:

  • Apoptotic endothelial cell-derived MPs increased in T2DM patients.
  • Activated endothelial cell-derived MP levels were lower in T2DM patients compared to controls.
  • Elevated CD31+/annexin V+ MPs and reduced CD62E+ MPs correlate with asymptomatic atherosclerosis in T2DM.
Keywords:
Asymptomatic atherosclerosisCardiovascular risk factorsCirculating microparticlesDiabetes mellitus

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