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Published on: August 15, 2016
In vivo in silico pharmacokinetic simulation studies of carvedilol-loaded nanocapsules using GastroPlus
Jerome K George1, Sandeep Kumar Singh1, P R P Verma1
1Department of Pharmaceutical Science & Technology, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand, India.
Background:
The study aimed at in vivo pharmacokinetic evaluation of carvedilol loaded nanocapsules (CLN) followed by in silico predictions and establishment of IVIVC.
Method:
LC/MS-MS method was developed and validated to estimate the pharmacokinetic profile of CLN. The in silico and IVIVC were established using GastroPlus.
Results:
The CLN demonstrated 221.09% increase in bioavailability of carvedilol over aqueous suspension. The simulation of plasma concentration profile of CLN exhibited a sensible level of superimposition. The regional absorption of the CLN showed maximum absorption from duodenum and jejunum. The Wagner-Nelson method was found to be most suitable deconvolution method for establishing the IVIVC of CLN.
Conclusion:
The study demonstrated CLN as efficient delivery system to ferry carvedilol with improved bioavailability.
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