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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Related Experiment Video

Updated: Mar 22, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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[Malignant lymphoma].

Harumi Kato1, Tomohiro Kinoshita

  • 1Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|April 15, 2016
PubMed
Summary
This summary is machine-generated.

Malignant lymphomas are diverse lymphoid cancers. Understanding their unique molecular profiles, including mutations and signaling pathways, is key to developing targeted therapies and predictive biomarkers for better treatment outcomes.

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Area of Science:

  • Hematology
  • Oncology
  • Genomics

Context:

  • Malignant lymphomas are a heterogeneous group of lymphoid neoplasms.
  • Advancements in high-throughput technologies and human genome knowledge are crucial for understanding lymphoma subtypes.

Purpose:

  • To review the current understanding of molecular mechanisms in lymphomas.
  • To discuss novel molecular target drugs and their efficacy in lymphoma treatment.

Summary:

  • High-throughput technologies reveal specific mutations, epigenetic alterations, and signaling pathways in lymphoma subtypes.
  • The mutational landscape of tumors influences the identification of molecular targets and predictive biomarkers for novel therapies.

Impact:

  • This review provides insights into molecular mechanisms driving lymphoma development.
  • It highlights the potential of molecularly targeted drugs and predictive biomarkers for advancing lymphoma therapy.