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Updated: Mar 22, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Acute respiratory distress syndrome: Pulmonary and extrapulmonary not so similar
Inderpaul Singh Sehgal1, Sahajal Dhooria1, Digambar Behera1
1Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Abstract:
Acute respiratory distress syndrome (ARDS) is characterized by acute onset respiratory failure with bilateral pulmonary infiltrates and hypoxemia. Current evidence suggests different respiratory mechanics in pulmonary ARDS (ARDSp) and extrapulmonary ARDS (ARDSexp) with disproportionate decrease in lung compliance in the former and chest wall compliance in the latter. Herein, we report two patients of ARDS, one each with ARDSp and ARDSexp that were managed using real-time esophageal pressure monitoring using the AVEA ventilator to tailor the ventilatory strategy.
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