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Body Composition and Metabolic Caging Analysis in High Fat Fed Mice
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Modeling Energy Dynamics in Mice with Skeletal Muscle Hypertrophy Fed High Calorie Diets
Nichole D Bond1, Juen Guo2, Kevin D Hall2
11. Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 USA;
International Journal of Biological Sciences
|April 15, 2016
Summary
Mice with inhibited myostatin (a muscle growth regulator) better balance energy intake and output, resisting weight gain on varied diets. This study reveals enhanced metabolic adaptability in muscular mice.
Area of Science:
- Exercise Physiology
- Metabolic Regulation
- Muscle Biology
Background:
- Lean mass and strength are linked to metabolic health.
- Myostatin inhibition increases muscle mass and obesity resistance in mice.
- Previous explanations for leanness in muscular mice are incomplete.
Purpose of the Study:
- To investigate dynamic changes in energy metabolism in muscular mice.
- To utilize a computational model for analyzing energy output, intake, and substrate oxidation.
- To understand how muscle-specific myostatin inhibition affects energy balance and diet adaptation.
Main Methods:
- Employing a computational model to estimate energy expenditure, fat oxidation, and respiratory quotient.
- Comparing muscular mice (dominant negative activin receptor IIB in muscle) with wild-type (WT) mice.
- Administering chow or high-fat diets for 15 weeks and assessing dietary choices and intake adjustments.
Main Results:
- Muscular mice exhibited higher food intake and energy output on both chow and high-fat diets.
- Transgenic mice demonstrated improved matching of fat oxidation to fat intake.
- Muscular mice showed superior ability to adjust caloric intake when switching between diets and preferred nutrient-rich options.
Conclusions:
- Muscle-specific myostatin inhibition enhances energy intake and output regulation.
- Muscular mice exhibit improved metabolic flexibility and resistance to weight gain.
- These findings provide insights into the role of muscle mass in maintaining energy homeostasis.
